Recebi este artigo via Medscape.
No caso , parece que o hormônio feminino estradiol é que teria efeito terapeutico para esquizofrenia em mulheres.
[Estrogen Relieves Psychotic Symptoms in Women With Schizophrenia CME
News Author: Marlene Busko
CME Author: Désirée Lie, MD, MSEd
Release Date: August 7, 2008; Valid for credit through August 7, 2009
Authors and Disclosures
Disclosure: Marlene Busko has disclosed no relevant financial relationships.
Désirée Lie, MD, MSEd
Disclosure: Désirée Lie, MD, MSEd, has disclosed no relevant financial relationships.
Brande Nicole Martin
Disclosure: Brande Nicole Martin has disclosed no relevant financial information.
August 7, 2008 — In women with severe schizophrenia, adding 100 µg a day of transdermal estradiol significantly reduced symptoms compared with antipsychotic medication alone.
The 28-day double-blind, placebo-controlled study extends and confirms previous findings by investigators led by psychiatrist Jayashri Kulkarni, PhD, at the Alfred and Monash University in Melbourne, Australia.
"There is a lot to be done, but I believe that we have opened up a new and promising area of treatment for a debilitating illness in both men and women," said Dr. Kulkarni.
These findings also validate the observation by many women that exacerbation or recurrence of psychosis is observed during low-estrogen phases of the menstrual cycle, and symptoms improve during high estrogen phases, she told Medscape Psychiatry.
In the current study, compared with women in the placebo group, those in the estradiol group exhibited a significantly greater improvement in positive and in general psychopathologic symptoms, as measured by the Positive and Negative Syndrome Scale (PANSS), she noted.
A subgroup of approximately 12 women made a "truly dramatic" recovery, going from a PANSS score of approximately 80 to a score of 10, she added.
The study is published in the August issue of the Archives of General Psychiatry.